منابع مشابه
NADPH Oxidases in Innate Immunity
and Duox in the respiratory epithelium. The location of these ROS-generating enzymes in the barrier tissues has prompted the expectation of their participation in host defense against invading pathogens in these tissues. Indeed, recent studies have begun to support this expectation, demonstrating roles in bacterial killing, cytokine production, apoptosis, gene expression and signaling, includin...
متن کاملNADPH Oxidases in Innate Immunity
and Duox in the respiratory epithelium. The location of these ROS-generating enzymes in the barrier tissues has prompted the expectation of their participation in host defense against invading pathogens in these tissues. Indeed, recent studies have begun to support this expectation, demonstrating roles in bacterial killing, cytokine production, apoptosis, gene expression and signaling, includin...
متن کاملNADPH oxidases in innate immunity.
and Duox in the respiratory epithelium. The location of these ROS-generating enzymes in the barrier tissues has prompted the expectation of their participation in host defense against invading pathogens in these tissues. Indeed, recent studies have begun to support this expectation, demonstrating roles in bacterial killing, cytokine production, apoptosis, gene expression and signaling, includin...
متن کاملOxidative innate immune defenses by Nox/Duox family NADPH oxidases.
The importance of reactive oxygen species (ROS) in innate immunity was first recognized in professional phagocytes undergoing a 'respiratory burst'upon activation. This robust oxygen consumption is related to a superoxide-generating enzyme, the phagocytic NADPH oxidase (Nox2-based or phox). The oxidase is essential for microbial killing, since patients lacking a functional oxidase suffer from e...
متن کاملNOX Family NADPH Oxidases
Proton channels allow cells to extrude excess acid with a high efficiency and therefore are one of the important homeostatic mechanisms that maintain the intracellular pH in a range compatible with life. Proton currents are highly expressed in phagocytes where they are thought to contribute to charge and pH compensation during NADPH oxidase activation. By analogy with the cytochrome C oxidase o...
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ژورنال
عنوان ژورنال: Journal of Innate Immunity
سال: 2009
ISSN: 1662-8128,1662-811X
DOI: 10.1159/000235859